Umucyo uri ku mpera z'umutuku n'iz'imirasire hafi ya infrared wihutisha gukira mu turemangingo twose n'uturemangingo. Bumwe mu buryo babigeraho ni ugukora nk'ibintu bikomeye birwanya okiside. Binabuza ikorwa rya okiside nitrique.
Ese urumuri rutukura n'urumuri rurerure rushobora gukumira cyangwa gusubiza inyuma ububabare bwo kutumva?
Mu bushakashatsi bwakozwe mu 2016, abashakashatsi bakoresheje urumuri rwa hafi ya infrared ku tunyangingo tw’amatwi mu buryo bwa vitro mbere yo kuzishyira mu kaga gakomeye ka ogisijeni mu kuzishyira mu kaga gatandukanye. Nyuma yo gushyira utwo tunyangingo twabanje kurwara uburozi bwa chimiotherapie na endotoxin, abashakashatsi basanze urwo rumuri rwahinduye imikorere ya mitochondrial na oxidative stress mu gihe cy’amasaha 24 nyuma yo kuvurwa.
Abanditsi b’ubushakashatsi banditse bati: “Turatangaza ko hari igabanuka rya cytokines zitera ububabare n’urugero rw’imihangayiko bituruka kuri NIR ishyirwa ku turemangingo tw’amatwi twa HEI-OC1 mbere yo kuvurwa na gentamicin cyangwa lipopolysaccharide.”
Ibisubizo by’ubushakashatsi byagaragaje ko kuvurwa mbere hakoreshejwe urumuri rwa infrared byagabanyije ibimenyetso by’ububyimbirwe bifitanye isano n’ubwiyongere bw’ubwoko bwa ogisijeni na okiside nitrique.
Inyigo ya 1: Ese urumuri rutukura rushobora gusubiza inyuma ikibazo cyo kutumva?
Ingaruka z'urumuri rwa hafi ya infrared ku kubura amatwi nyuma yo kuvurwa na chemotherapy zarasuzumwe. Kumva byasuzumwe nyuma yo guhabwa gentamicin ndetse no nyuma y'iminsi 10 yo kuvurwa n'urumuri.
Ku bijyanye no gusuzuma amashusho ya elegitoroniki, “LLLT yongereye cyane umubare w’uturemangingo tw’umusatsi mu mizunguruko yo hagati n’iyo hasi. Kumva byarushijeho kuba byiza bitewe n’imirasire ya laser. Nyuma yo kuvurwa na LLLT, umubare w’uturemangingo tw’umusatsi n’uw’uturemangingo tw’umusatsi wariyongereye cyane.”
Inyigo ya 2: Ese urumuri rutukura rushobora gusubiza inyuma ikibazo cyo kutumva?
Muri ubu bushakashatsi, imbeba zahuye n'urusaku rwinshi mu matwi yombi. Nyuma yaho, amatwi yazo y'iburyo yacanishijwe urumuri rurerure rwa infrared mu gihe cy'iminota 30 buri munsi mu gihe cy'iminsi 5.
Gupima uko ubwonko bw’umuntu buhagaze byagaragaje ko imikorere y’amatwi yihutishijwe mu matsinda yavuwe na LLLT yagarutse vuba ugereranije n’itsinda ritavuwe ku munsi wa 2, uwa 4, uwa 7 n’uwa 14 nyuma yo kumva urusaku. Ibipimo byagaragaje kandi ko uturemangingo tw’umusatsi wo hanze twari dufite igipimo cyo kubaho kiri hejuru cyane mu matsinda ya LLLT.
Mu gushaka ibimenyetso by'umuvuduko wa ogisijeni na apoptosis mu turemangingo tutavuwe ugereranyije n'uko twavuwe, abashakashatsi basanze "Ibikorwa bikomeye by'ubudahangarwa bw'umubiri byagaragaye mu bice by'imbere by'amatwi by'itsinda ritavuwe, mu gihe ibi bimenyetso byagabanutse mu itsinda rya LLLT ku bucucike bwa 165mW/cm(2)."
"Ibyavuye mu bushakashatsi bwacu bigaragaza ko LLLT igira ingaruka zo kurinda NIHL binyuze mu gukumira iNOS no kugabanya apoptosis."
Inyigo ya 3: Ese urumuri rutukura rushobora gusubiza inyuma ikibazo cyo kutumva?
Mu bushakashatsi bwakozwe mu 2012, imbeba icyenda zahuye n'urusaku rwinshi kandi hageragejwe ikoreshwa ry'urumuri rwa hafi ya infrared mu gusubiza amatwi. Umunsi umwe nyuma y'aho zahuye n'urusaku rwinshi, amatwi y'ibumoso y'imbeba yavuwe n'urumuri rwa hafi ya infrared mu gihe cy'iminota 60 mu gihe cy'iminsi 12 yikurikiranya. Amatwi y'iburyo ntiyavuwe kandi yafashwe nk'itsinda rishinzwe kuyagenzura.
“Nyuma y’imirasire ya 12, umubare w’amatwi y’ibumoso wari uri hasi cyane ugereranije n’amatwi y’iburyo.” Iyo byagaragaye hakoreshejwe mikorosikopi ya elegitoroniki, umubare w’uturemangingo tw’ubwoya bw’amatwi mu matwi yavuwe wari munini cyane ugereranyije n’uw’amatwi atavuwe.
“Ibyavuye mu bushakashatsi bwacu bigaragaza ko imirasire ya laser yo ku rwego rwo hasi ituma ubushobozi bwo kumva bugaruka nyuma y’ihungabana rikomeye ry’amajwi.”