Indwara ya Alzheimer, indwara igenda itera indwara ya neurodegenerative, igaragarira mu bimenyetso nko guta umutwe, apasiya, agnosia, no kutagira imikorere myiza. Ubusanzwe, abarwayi bashingiye ku miti yo kugabanya ibimenyetso. Icyakora, kubera imbogamizi n'ingaruka zishobora guterwa nibi biyobyabwenge, abashakashatsi berekeje ibitekerezo byabo kuri Phototherapie idatera, bagera ku ntera ishimishije mumyaka yashize.
Vuba aha, itsinda riyobowe na Porofeseri Zhou Feifan wo muri kaminuza ya Biomedical Engineering College ya kaminuza ya Hainan ryavumbuye ko imiti itavura imibonano mpuzabitsina ishobora kugabanya ibimenyetso by’indwara kandi ikongerera ubushobozi bwo kumenya mu mbeba zashaje na Alzheimer. Ubu bushakashatsi bwibanze, bwasohotse mu kinyamakuru Nature Communications, butanga ingamba zitanga ikizere cyo kurwanya indwara zifata ubwonko.
Gusobanukirwa Indwara ya Alzheimer
Impamvu nyayo itera Alzheimer ntisobanutse neza, ariko irangwa na beta-amyloide proteine idasanzwe hamwe na neurofibrillary tangles, biganisha ku mikorere mibi ya neuronal no kugabanuka kwubwenge. Ubwonko, nkumubiri ukora cyane muburyo bwimikorere, butanga imyanda ikomeye ya metabolike mugihe cyimikorere. Kurundanya cyane iyi myanda birashobora kwangiza neuron, bisaba kuvanaho neza binyuze muri sisitemu ya lymphatique.
Imiyoboro ya lymphatike ya meningeal, ingenzi cyane mu kuvoma imiyoboro yo hagati y’imitsi, igira uruhare runini mu gukuraho poroteyine zifite ubumara bwa beta-amyloide, imyanda ya metabolike, no kugenzura ibikorwa by’ubudahangarwa, bigatuma iba intego yo kuvura.
Ingaruka ya Phototherapy kuri Alzheimer
Itsinda rya Porofeseri Zhou ryakoresheje nm 808 nm hafi ya lazeri ya infragre mu byumweru bine bya fototerapi idahuye n’imbeba zashaje na Alzheimer. Ubu buvuzi bwongereye cyane imikorere ya selile lymphatic endothelial selile, kunoza imiyoboro ya lymphatike, no kugabanya ibimenyetso byindwara ndetse no kunoza imikorere yubwenge mumbeba.
Guteza imbere imikorere ya Neuronal binyuze muri Phototherapy
Phtotherapy irashobora kuzamura no kunoza imikorere ya neuronal binyuze muburyo butandukanye. Kurugero, inzira yumubiri igira uruhare runini muri patologiya ya Alzheimer. Ubushakashatsi buherutse gukorwa bwerekana ko imirasire ya 532 nm icyatsi kibisi gishobora kongera imikorere yingirabuzimafatizo, bigatera uburyo bwimikorere muri neurone yo hagati, kunoza imitsi, no kongera umuvuduko wamaraso nibimenyetso byindwara kubarwayi ba Alzheimer. Imirasire yambere yicyatsi kibisi cyerekanaga iterambere ryinshi mumitsi, plasma viscosity, gukusanya amaraso atukura, hamwe no gupima neuropsychologue.
Umuti utukura kandi utagira urumuri (Photobiomodulation) ukoreshwa mubice byumubiri byumubiri (umugongo namaguru) birashobora gukora ingirabuzimafatizo z'umubiri cyangwa ingirabuzimafatizo zikingira umubiri, bikagira uruhare mubuzima bwa neuronal no kwerekana gene nziza.
Kwangiza Oxidative nabyo ni inzira ikomeye yindwara ya Alzheimer. Ubushakashatsi bwerekana ko imirasire yumucyo itukura ishobora kongera ibikorwa bya selile ya ATP, bigatera ihinduka ryimikorere kuva glycolysis ikajya mubikorwa bya mitochondrial muri microglia yanduye yibasiwe na oligomeric beta-amyloide, kongera urugero rwa microglia anti-inflammatory, kugabanya cytokine itera inflammatory, no gukora fagocytose kugirango wirinde neuronal urupfu.
Gutezimbere kuba maso, kubimenya, no kwitabwaho bihoraho nubundi buryo bufatika bwo kuzamura imibereho yabarwayi ba Alzheimer. Abashakashatsi basanze ko guhura nuburebure bugufi-bwumurabyo wubururu bigira ingaruka nziza kumikorere yubwenge no kugenzura amarangamutima. Imirasire yubururu irashobora guteza imbere ibikorwa byumuzunguruko, bigira ingaruka kumikorere ya acetylcholinesterase (AchE) na choline acetyltransferase (ChAT), bityo bikazamura ubushobozi bwo kwiga no kwibuka.
Ingaruka nziza ya Phototherapy kuri Neuron yubwonko
Umubiri ukura mubushakashatsi bwemewe uremeza ingaruka nziza ya Phototherapy kumikorere yubwonko bwa neuron. Ifasha gukora ingirabuzimafatizo z'umubiri zirinda umubiri, igatera imiterere ya gene ya neuronal kubaho, kandi ikaringaniza urugero rwa ogisijeni ya mitochondrial reaction. Ibyavuye mu bushakashatsi bishyiraho urufatiro rukomeye rwo kuvura amafoto.
Hashingiwe kuri ubwo bushishozi, Ikigo cy’ubushakashatsi cy’ingufu cya MERIKANI, ku bufatanye n’itsinda ry’Abadage na za kaminuza nyinshi, ubushakashatsi, n’ibigo by’ubuvuzi, bakoze ubushakashatsi bwerekeye abantu bafite hagati y’imyaka 30-70 bafite ubumuga buke bwo kutamenya, kugabanuka mu mutwe, kugabanya gusobanukirwa no guca imanza, no kugabanya ubushobozi bwo kwiga. Abitabiriye amahugurwa bakurikije umurongo ngenderwaho w’imirire n’ubuzima bwiza mugihe barimo gukorerwa amafoto mu kazu k’ubuzima ka MERIKA, hamwe n’imiti ihoraho hamwe na dosiye.
Nyuma y'amezi atatu yipimishije rya neuropsychologue, ibizamini byo mumitekerereze, hamwe nisuzuma ryubwenge, ibisubizo byagaragaje iterambere ryinshi mumanota MMSE, ADL, na HDS mubakoresha amafoto yubuzima bwa cabine. Abitabiriye amahugurwa kandi bagize uburambe bwo kureba neza, gusinzira neza, no kugabanya amaganya.
Ubu bushakashatsi bwerekana ko gufotora bishobora kuba ubuvuzi bufasha kugenzura imikorere yubwonko bwubwonko, kugabanya neuroinflammation na patologi bifitanye isano, kunoza ubumenyi, no kongera kwibuka. Byongeye kandi, ifungura inzira nshya zo gufotora kugirango zihinduke muburyo bwo kuvura.
