Rosacea nuburyo busanzwe burangwa no gutukura mumaso no kubyimba.Ifata abagera kuri 5% byabatuye isi, kandi nubwo ibitera bizwi, ntabwo bizwi cyane.Bifatwa nk'uruhu rurerure, kandi bikunze kwibasira abagore b'Abanyaburayi / Caucase barengeje imyaka 30. Hariho ubwoko butandukanye bwa rosacea kandi bushobora kugira ingaruka kuri buri wese.
Ubuvuzi butukura bwizwe neza kubintu nko gukiza uruhu, gutwika muri rusange, kolagen mu ruhu, hamwe nuburyo butandukanye bwuruhu nka acne.Mubisanzwe inyungu ziyongereye mugukoresha itara ritukura kuri rosacea.Muri iki kiganiro tuzareba niba kuvura itara ritukura (nanone bizwi nka Photobiomodulation, LED therapy, therapy laser, laser laser, therapy light, LLLT, nibindi) bishobora gufasha kuvura rosacea.
Ubwoko bwa Rosacea
Umuntu wese ufite rosacea afite ibimenyetso bitandukanye kandi bidasanzwe.Mugihe rosacea isanzwe ifitanye isano no gutukura mumaso izuru no mumatama, hari ibindi bimenyetso bitandukanye bishobora gucika hanyuma bigashyirwa mubice bya rosacea 'subtypes':
Subtype 1, yitwa 'Erythematotelangiectatic Rosacea' (ETR), ni rosacea itagaragara yerekana umutuku wo mumaso, gutwika uruhu, imiyoboro y'amaraso hafi yubuso n'ibihe byo gutemba.Erythema ikomoka ku ijambo ry'Ikigereki erythros, risobanura umutuku - kandi ryerekeza ku ruhu rutukura.
Subtype 2, Acne rosacea (izina ry'ubumenyi - papulopustular), ni rosacea aho uruhu rutukura ruhujwe no guhora cyangwa rimwe na rimwe acne imeze nka breakout (pustules na papules, ntabwo ari umukara).Ubu bwoko bushobora gutera gutwika cyangwa gukomeretsa.
Subtype 3, AKA phymatous rosacea cyangwa rhinophyma, nuburyo budasanzwe bwa rosacea kandi burimo ibice byo mumaso bigenda byiyongera kandi binini - mubisanzwe izuru (izuru ryibirayi).Bikunze kugaragara mubagabo bakuze kandi mubisanzwe bitangira nkubundi bwoko bwa rosacea.
Subtype ya 4 ni rosacea yijisho, cyangwa ocular rosacea, kandi ikubiyemo amaso yamaraso, amaso yamazi, kumva ikintu mumaso, gutwika, guhinda no gukonja.
Kumenya subtypes ya rosacea nibyingenzi mukumenya niba koko uyifite.Niba ntakintu cyakozwe kugirango gikemure rosacea, gikunda kuba kibi mugihe.Kubwamahirwe, uburyo bwo kuvura urumuri rutukura kuvura rosacea ntabwo bihinduka hamwe na subtype.Ubusobanuro bumwe bwumutuku utukura protocole yakora kuri subtypes zose.Kubera iki?Reka turebe ibitera rosacea.
Impamvu nyayo ya Rosacea
(… Nimpamvu kuvura urumuri bishobora gufasha)
Mu myaka mirongo ishize, rosacea yabanje kwizera ko ari ingaruka ziterwa na bagiteri.Nkuko antibiyotike (harimo na tetracycline) yakoraga kurwego rwo gucunga ibimenyetso, byasaga nkigitekerezo cyiza… .ariko byihuse byaje kugaragara ko nta bagiteri zirimo.
Abaganga benshi ninzobere kuri rosacea muriyi minsi bazakubwira ko rosacea idasobanutse kandi ntamuntu numwe wabimenye.Bamwe bazerekana mite ya Demodex nkimpamvu, ariko hafi ya bose bafite ibi kandi ntabwo bose bafite rosacea.
Noneho bazahitamo gutondeka 'imbarutso' zitandukanye mu mwanya wabitera, cyangwa batange ibitekerezo byerekana genetiki idasobanutse nibintu bidukikije aribyo bitera.Nubwo ibintu bya genetike cyangwa epigenetike bishobora guteganya umuntu kurwara rosacea (ugereranije nundi muntu), ntibabimenya - ntabwo arimpamvu.
Impamvu zitandukanye zigira uruhare rwose muburemere bwibimenyetso bya rosacea (cafeyine, ibirungo, ibiryo bimwe na bimwe, ikirere gikonje / ubushyuhe, imihangayiko, inzoga, nibindi), ariko nazo ntabwo arizo ntandaro.
None ni iki?
Ibimenyetso
Ibimenyetso byambere kubitera ni mubyukuri rosacea ikura nyuma yimyaka 30. Iyi niyo myaka ibimenyetso byambere byo gusaza bigaragara.Abantu benshi bazabona umusatsi wabo wambere wumusatsi hamwe nuruhu rwambere rwuruhu rwinshi muriyi myaka.
Ikindi kimenyetso ni uko antibiyotike ifasha gucunga ibimenyetso - nubwo nta bwandu bufatika (bwerekana: antibiotique ishobora kugira ingaruka zigihe gito zo kurwanya inflammatory).
Amaraso atembera kuruhu rwibasiwe na rosacea yikubye inshuro 3 kugeza kuri 4 kurenza uruhu rusanzwe.Izi ngaruka za hyperemia zibaho mugihe ingirabuzimafatizo na selile zidashobora gukuramo ogisijeni mumaraso.
Turabizi ko rosacea atari ikibazo cyo kwisiga gusa, ahubwo ikubiyemo impinduka zikomeye zo gukura kwa fibrotic kuruhu (niyo mpamvu izuru ryibirayi muburyo bwa 3) no gukura kwimitsi y'amaraso itera (niyo mpamvu imitsi / flushing).Iyo ibyo bimenyetso bimwe bibaye ahandi mu mubiri (urugero: fibroide ya nyababyeyi) barasaba ko hakorwa iperereza rikomeye, ariko muruhu birukanwa nkibibazo byo kwisiga kugirango 'bicungwe' n '' kwirinda imbarutso ', nyuma ndetse no kubagwa kugirango bakureho uruhu rwijimye. .
Rosacea nikibazo gikomeye kuko intandaro ni inzira ya physiologique yimbitse mumubiri.Imiterere ya physiologiya iganisha kuri izi mpinduka zuruhu ntabwo zigira ingaruka kuruhu gusa - igira ingaruka kumubiri wose w'imbere.
Kuzunguruka, gukura / gutera imiyoboro y'amaraso no kubyimba uruhu birashobora kugaragara byoroshye muri rosacea, kuko bigaragara muruhu - hejuru yumubiri.Mu buryo bumwe, ni umugisha kubona ibimenyetso bya rosacea, kuko bikwereka ko hari ibitagenda neza imbere.Gutakaza umusatsi wumugabo nikintu gisa nacyo kuko cyerekana imisemburo idasanzwe.
Inenge ya Mitochondrial
Ibiteganijwe byose hamwe n'ibipimo byerekeranye na rosacea byerekana ibibazo bya mitochondial nkintandaro ya rosacea.
Mitochondria ntishobora gukoresha ogisijeni neza iyo yangiritse.Kudashobora gukoresha ogisijeni byongera amaraso mu ngingo.
Mitochondria itanga aside ya lactique mugihe idashobora kubona no gukoresha ogisijeni, biganisha kuri vasodilasiyo no gukura kwa fibroblast.Niba iki kibazo kimaze igihe kinini, imiyoboro mishya y'amaraso itangira gukura.
Ibintu bitandukanye bya hormone nibidukikije birashobora kugira uruhare mumikorere mibi ya mito-iyambere, ariko murwego rwo kuvura urumuri rutukura, ingaruka zikomeye ni molekile yitwa Nitric Oxide.
Ubuvuzi butukura hamwe na Rosacea
Igitekerezo nyamukuru gisobanura ingaruka zo kuvura urumuri rushingiye kuri molekile yitwa Nitric Oxide (OYA).
Iyi ni molekile ishobora kugira ingaruka zitandukanye kumubiri, nko kubuza kubyara ingufu, vasodilation / kwagura imiyoboro y'amaraso, nibindi.Icyo dushishikajwe cyane no kuvura urumuri ni uko iyi OYA ihuza ahantu h'ingenzi mu ruhererekane rwo gutwara abantu rwa mitochondial, guhagarika ingufu.
Ihagarika ibyiciro byanyuma byo guhumeka, bityo ikaguhagarika kubona igice kinini cyingufu (ATP) na dioxyde de carbone iyo ari yo yose ya glucose / ogisijeni.Iyo rero abantu bagabanije burundu igipimo cya metabolike uko basaza cyangwa bahura nibihe byo guhangayika / inzara, iyi OYA mubisanzwe irashinzwe.Birumvikana iyo ubitekerejeho, muri kamere cyangwa mubuzima, ukeneye uburyo bwo kugabanya igipimo cya metabolike mugihe cyibiribwa bike / calorie iboneka.Ntabwo byumvikana cyane kwisi ya none aho NTA rwego rushobora guterwa nubwoko bwihariye bwa aside amine mumirire, ihumana ryikirere, ifu, izindi mpamvu zimirire, urumuri rwubukorikori, nibindi. Kubura dioxyde de carbone mumibiri yacu nayo ikongeza umuriro.
Ubuvuzi bworoheje bwongera umusaruro wingufu zombi (ATP) na karuboni ya dioxyde (CO2).CO2 nayo ibuza cytokine zitandukanye na prostaglandine.Ubuvuzi bworoshye rero bugabanya urugero rwumuriro mumubiri / agace.
Kuri rosacea ikintu cyingenzi gifata ni uko ubuvuzi bworoheje bugiye kugabanya gucana no gutukura muri kariya gace, kandi bikanakemura ikibazo cyo gukoresha ogisijeni nkeya (byatumye imitsi yamaraso ikura no gukura kwa fibroblast).
Incamake
Hano hari subtypes zitandukanye no kwigaragaza kwa rosacea
Rosacea ni ikimenyetso cyo gusaza, nk'iminkanyari n'imisatsi imeze
Intandaro ya rosacea igabanuka imikorere ya mitochondial selile
Umuti utukura utanga mitochondriya kandi ugabanya gucana, ukirinda rosacea
Igihe cyo kohereza: Nzeri-30-2022