Ubuvuzi bworoheje bwo kubyara no gusama

Kutabyara no kutabyara biriyongera, haba ku bagore no ku bagabo, ku isi yose.

Kutabyara ni ukudashobora, nk'abashakanye, gusama nyuma y'amezi 6 - 12 yo kugerageza.Kutabyara bivuga kugira amahirwe make yo gusama, ugereranije nabandi bashakanye.

Bigereranijwe ko 12-15% byabashakanye bashaka, ariko ntibabashe gusama.Kubera iyo mpamvu, kuvura uburumbuke nka IVF, IUI, uburyo bwa hormone cyangwa ibiyobyabwenge, uburyo bwo kubaga, nibindi, biriyongera cyane mubyamamare.

Ubuvuzi bworoshye (rimwe na rimwe bizwi nkaPhotobiomodulation, LLLT, kuvura itara ritukura, laser ikonje, nibindi.) yerekana amasezerano yo kuzamura ubuzima bwibice byinshi byumubiri bitandukanye, kandi byakozweho ubushakashatsi kuburumbuke bwumugore nuburumbuke bwumugabo.Ubuvuzi bworoheje bwo kuvura uburumbuke bwemewe?Muri iki kiganiro tuzaganira ku mpamvu urumuri rushobora kuba icyo ukeneye…

Intangiriro
Kutabyara ni ikibazo ku isi hose ku bagabo no ku bagore, aho uburumbuke bugabanuka vuba, mu bihugu bimwe cyane kuruta ibindi.10% by'abana bose bavukiye muri Danimarike batwite babifashijwemo na IVF hamwe n’ikoranabuhanga rishingiye ku myororokere.Abashakanye 1 kuri 6 mu Buyapani ntibabyara, leta y’Ubuyapani iherutse kugira icyo ikora kugira ngo yishyure amafaranga IVF y’abashakanye mu rwego rwo guhagarika ikibazo cy’abaturage kigaragara.Guverinoma muri Hongiriya, yifuza cyane kongera umubare muto w'abana bavuka, yabigize bityo abagore bafite abana 4 cyangwa barenga bazasonerwa ubuzima bwabo bwose kugira ngo batange umusoro ku nyungu.Kubyara ku mugore mu bihugu bimwe na bimwe by’Uburayi biri munsi ya 1.2, ndetse no kuri 0.8 muri Singapuru.

Umubare w'abana bavuka wagabanutse ku isi hose, kuva byibura 1950 no mu turere tumwe na tumwe mbere yabyo.Ntabwo ubugumba bwabantu gusa bugenda bwiyongera, amoko atandukanye yinyamanswa nayo afite ibibazo, nkubuhinzi n’amatungo yo mu rugo.Bimwe mubyo kugabanuka kwababyaye biterwa nimpamvu zubukungu nubukungu - abashakanye bahitamo kugerageza kubana nyuma, mugihe uburumbuke busanzwe bumaze kugabanuka.Ikindi gice cyo kugabanuka ni ibidukikije, imirire ndetse na hormone.Kurugero kubara intanga mubigabo byabagabo byagabanutseho 50% mumyaka 40 ishize.Abagabo rero muri iki gihe batanga gusa kimwe cya kabiri cyintanga ngabo nkuko ba sekuru na basogokuruza babigize mubusore bwabo.Indwara yimyororokere yumugore nka syndrome ya polycystic ovarian syndrome (PCOS) ubu yibasira abagore bagera kuri 10%.Endometriose (imiterere aho uturemangingo twa nyababyeyi dukurira mu tundi turere tw’imyororokere) nayo yibasira abandi 1 ku bagore 10, bityo abagore bagera kuri miliyoni 200 ku isi.

Ubuvuzi bworoheje nigitekerezo gishya cyo kuvura ubugumba, kandi nubwo igwa munsi ya 'ART' (ifashwa n’ikoranabuhanga ryimyororokere) ifashwa na IVF, ni bihendutse cyane, idatera, kandi byoroshye kubona imiti.Ubuvuzi bworoheje bwashyizweho cyane mugukemura ibibazo byubuzima bwamaso, ibibazo byububabare, byakiza, nibindi, kandi burimo kwigwa cyane kwisi yose mubihe bitandukanye nibice byumubiri.Byinshi mu bivura urumuri rwubushakashatsi bwuburumbuke biva mubihugu 2 - Ubuyapani na Danemark - cyane cyane kubushakashatsi ku myororokere y'abagore.

Uburumbuke bw'umugore
50%, hafi kimwe cya kabiri, mubashakanye bose batabyara biterwa nimpamvu zumugore gusa, naho 20% zikaba ari ihuriro ryuburumbuke bwumugore nigitsina gabo.Hafi ya 7 kuri buri 10ikibazo cyo gusama kirashobora kunozwa mugukemura ubuzima bwimyororokere yumugore.

Ibibazo bya tiyideyide na PCOS biri mubitera kutabyara, byombi ntibisuzumwe cyane (Soma byinshi kubyerekeye ubuzima bwa tiroyide hamwe nubuvuzi bworoshye hano).Endometriose, fibroide nibindi bikura byimbere byimbere bigira ikindi gice kinini cyimibare yuburumbuke.Iyo umugore atabyara, 30% + yigihe hazaba hari urugero rwa endometriose.Izindi mpamvu zitera ubugumba ni;guhagarika imiyoboro ya fallopian, inkovu zimbere ziva kubagwa (harimo C-ibice), nibindi bibazo bya ovulation usibye pcos (anovulation, idasanzwe, nibindi).Mubihe byinshi igitera ubugumba ntigisobanuwe gusa - ntabwo bizwi impamvu.Rimwe na rimwe, gusama no gutera amagi bibaho, ariko mugihe cyo gutwita hakiri kare habaho gukuramo inda.

Hamwe n'ubwiyongere bwihuse bwibibazo byuburumbuke, habayeho kwiyongera muburyo bwo kuvura ubugumba nubushakashatsi.Ubuyapani nkigihugu gifite kimwe mubibazo by’uburumbuke bukabije ku isi, hamwe n’igipimo kinini cyo gukoresha IVF.Ni abambere mu kwiga ingaruka zo kuvura urumuri ku kuzamura uburumbuke bw'umugore….

Ubuvuzi bworoheje n'uburumbuke bw'umugore
Ubuvuzi bwumucyo bukoresha urumuri rutukura, hafi yumucyo wa infragre, cyangwa guhuza byombi.Ubwoko bwiza bwurumuri kubwintego yihariye buratandukanye ukurikije igice cyumubiri.

Iyo urebye uburumbuke bwumugore byumwihariko, intego yibanze ni nyababyeyi, intanga ngore, imiyoboro ya fallopian na sisitemu rusange ya hormone (tiroyide, ubwonko, nibindi).Izi nyama zose ziri imbere mumubiri (bitandukanye nibice byimyororokere yumugabo), nuko rero ubwoko bwurumuri hamwe no kwinjirira neza birakenewe, kuko ijanisha rito ryumucyo ukubita uruhu rizinjira mubice nka ovaries.Ndetse hamwe nuburebure bwumurongo utanga uburyo bwiza bwo kwinjira, umubare winjira uracyari muto cyane, nuko rero imbaraga nyinshi zumucyo zirakenewe.

Hafi yumucyo wa infragreire yuburebure buri hagati ya 720nm na 840nm bifite uburyo bwiza bwo kwinjira mubice byumubiri.Uru ruhererekane rw'urumuri ruzwi nka 'Hafi ya Infrared Window (mu binyabuzima)' kubera imiterere yihariye yo kunyura mu mubiri.Abashakashatsi bareba kunoza ubugumba bwumugore numucyo bahisemo cyane 830nm hafi yumurambararo wa infragre kugirango bakore ubushakashatsi.Ubu burebure bwa 830nm ntabwo bwinjira neza gusa, ahubwo bugira n'ingaruka zikomeye kuri selile zacu, kunoza imikorere yabyo.

Itara ku ijosi
Bumwe mu bushakashatsi bwakozwe mbere y’Ubuyapani bwari bushingiye kuri 'The Proximal Priority Theory'.Igitekerezo cyibanze nuko ubwonko arirwo rugingo nyamukuru rwumubiri kandi izindi ngingo zose hamwe na sisitemu ya hormone biri munsi yubwonko.Niba iki gitekerezo ari cyo cyangwa atari cyo, hari ukuri kuri kuri.Abashakashatsi bifashishije 830nm hafi y’urumuri rutagira ingano ku ijosi ry’abagore b’Abayapani batabyara, bizeye ko ingaruka zitaziguye kandi zitaziguye (binyuze mu maraso) ku bwonko amaherezo zizavamo imiterere myiza ya hormone na metabolike mu mubiri wose, cyane cyane imyororokere.Ibisubizo byari byiza, aho umubare munini wabagore babonaga ko 'batabyara cyane' badatwite gusa, ahubwo banagera no kubyara bazima - bakira umwana wabo mwisi.

Dukurikije ubushakashatsi bwakoresheje urumuri ku ijosi, abashakashatsi bashishikajwe no kumenya niba kuvura urumuri bishobora kuzamura igipimo cy’inda z’inda zisanzwe na IVF.

Muri vitro ifumbire izwi nkuburyo bwa nyuma mugihe uburyo gakondo bwo gusama bwananiranye.Igiciro kuri buri cyiciro kirashobora kuba kinini cyane, ndetse kikaba kidashoboka kubashakanye benshi, hamwe nabandi bafata inguzanyo nkumukino wo gutera inkunga.Intsinzi ya IVF irashobora kuba mike cyane cyane kubagore bafite imyaka 35 cyangwa irenga.Urebye ikiguzi kinini nigipimo gito cyo gutsinda, kunoza amahirwe ya cycle ya IVF ni ngombwa kugirango ugere ku ntego yo gutwita.Kurandura ibikenewe bya IVF no gutwita bisanzwe nyuma yizunguruka birananirana.

Igipimo cyo gutera amagi yatewe (ingenzi kuri IVF no gutwita bisanzwe) batekereza ko bifitanye isano nimikorere ya mito-iyambere.Gukora mitochondria yo hasi bidindiza imikorere ya selile yamagi.Mitochondriya iboneka mu ngirangingo z'amagi yarazwe na nyina, kandi irashobora kugira ihinduka rya ADN ku bagore bamwe na bamwe, cyane cyane uko imyaka igenda ishira.Umutuku kandi hafi ya infrarafarike ivura ikora neza kuri mitochondria, kunoza imikorere no kugabanya ibibazo nka mutation ya ADN.Ibi birasobanura impamvu ubushakashatsi bwakorewe muri Danimarike bwerekanye ko bibiri bya gatatu by'abagore babanje kunanirwa na IVF batwite neza (ndetse no gutwita bisanzwe) hamwe no kuvura urumuri.Ndetse habaye ikibazo cyumukecuru wimyaka 50 atwite.

Umucyo ku nda
Porotokole yakoreshejwe muri ubu bushakashatsi yaturutse muri Danimarike yitabiriye hafi ya infrarafarike yo kuvura imiti buri cyumweru, urumuri rushyirwa mu nda, ku kigero kinini.Niba umugore atasamye mugihe cyimihango, ubuvuzi bwakomeje mubukurikira.Mu cyitegererezo cy’abagore 400 batabyara mbere, 260 muri bo bashoboye gusama nyuma yo kuvura urumuri ruto.Kugabanuka ubwiza bwamagi ntabwo aribikorwa bidasubirwaho, byasa.Ubu bushakashatsi butera kwibaza inzira ya ART yo gukuramo intanga ngore yumugore no kuyinjiza mu ngirangingo y’amagi y’umuterankunga (uzwi ku izina rya mitochondrial transfert, orperson / ababyeyi bababyeyi) - birakenewe rwose mugihe ingirangingo y’amagi y’umugore ishobora kugarurwa. hamwe nubuvuzi budatera.

Gukoresha ubuvuzi bworoheje ku nda (kwibasira intanga ngore, nyababyeyi, igituba cya fallopian, selile yamagi, nibindi) bikekwa gukora muburyo 2.Ubwa mbere ni ugutezimbere ibidukikije byimyororokere, kwemeza ko amagi arekurwa mugihe cya ovulation, bishobora kugenda mumiyoboro ya fallopian, kandi birashobora kwinjizwa murukuta rwiza rwa nyababyeyi rufite amaraso meza, insimburangingo nzima irashobora gukora, nibindi. Ubundi buryo burimo kuzamura ubuzima bw'utugingo ngengabuzima.Ingirabuzimafatizo za Oocyte, cyangwa amagi, bisaba imbaraga nyinshi ugereranije nizindi selile kubikorwa bijyanye no kugabana no gukura.Izi mbaraga zitangwa na mitochondria - igice cyingirabuzimafatizo yibasiwe nubuvuzi bworoshye.Kugabanuka kwimikorere ya mitochondrial birashobora kugaragara nkimpamvu nyamukuru itera ingumba.Ibi birashobora kuba ibisobanuro byingenzi kubibazo byinshi byuburumbuke 'budasobanutse' nimpamvu uburumbuke bugabanuka uko imyaka igenda ishira - ingirangingo yamagi ntishobora gukora imbaraga zihagije.Ibimenyetso bisaba kandi bagakoresha ingufu nyinshi cyane tubisanga kuberako mitochondriya yikubye inshuro 200 mumasemburo yamagi ugereranije nizindi selile zisanzwe.Nibyo byikubye inshuro 200 ingaruka ninyungu zo kuvura urumuri ugereranije nizindi selile zo mumubiri.Muri buri selile yo mumubiri wose wumuntu, umugabo cyangwa umugore, selile yamagi irashobora kuba ubwoko bwakira ibintu bikomeye cyane bivuye kumutuku no hafi yumucyo wa infragre.Ikibazo gusa nukubona urumuri rwinjira muri ovaries (byinshi kuribi hepfo).

Izi miti zombi zivura urumuri cyangwa 'Photobiomodulation' hamwe hamwe bigira ubuzima bwiza nubusore, bikwiriye gushyigikira urusoro rukura.

Uburumbuke bwumugabo
Igitsina gabo nicyo gitera hafi 30% byabashakanye batabyara, hamwe nibintu byabagabo nabagore bingana na 20% hejuru yibyo.Kimwe cya kabiri cyigihe, kuzamura ubuzima bwimyororokere yumugabo bizakemura ibibazo byuburumbuke.Ibibazo byuburumbuke kubagabo mubisanzwe bihura nimikorere ya testicular yagabanutse, biganisha kukibazo cyintanga.Hariho izindi mpamvu zitandukanye nazo, nka;gusohora retrograde, gusohora kwumye, antibodies zitera intanga ngabo, nibintu byinshi bituruka ku moko n'ibidukikije.Kanseri n'indwara birashobora kwangiza burundu ubushobozi bwibizamini byo gukora intanga.

Ibintu nko kunywa itabi no kunywa inzoga buri gihe bigira ingaruka mbi cyane kumibare yintanga nubwiza bwintanga.Kunywa itabi rya kibyeyi ndetse bigabanya intsinzi ya cycle ya IVF igice.

Nyamara, hari ibidukikije nibiryo bishobora kuzamura intanga ngabo nubwiza, nko kunoza imiterere ya zinc no kuvura urumuri rutukura.

Umuti woroheje ntushobora kumenyekana mugukemura ibibazo byuburumbuke, ariko ubushakashatsi bwihuse kuri pubmed bugaragaza ubushakashatsi bwibihumbi.

Ubuvuzi bworoheje n'uburumbuke bw'abagabo
Ubuvuzi bworoheje (bita photobiomodulation) burimo gukoresha umutuku ugaragara, cyangwa utagaragara hafi ya infragre, urumuri kumubiri kandi rwizwe neza kubuzima bwintanga.

Ni ubuhe bwoko bw'urumuri bwiza kandi ni ubuhe burebure bwihariye?Umutuku, cyangwa hafi ya infragre?

Itara ritukura kuri 670nm kuri ubu nubushakashatsi bwakozwe neza kandi bunoze bwo kuzamura ubuzima bwimyororokere yumugabo nubwiza bwintanga.

Intangangabo zihuta, zikomeye
Ubushakashatsi bwerekana ko na nyuma yigihe kimwe gusa cyo kuvura urumuri rutukura, umuvuduko wintanga (umuvuduko wo koga) utera imbere cyane:

Kwihuta cyangwa umuvuduko wintangangabo ningirakamaro cyane muburumbuke, kuko nta muvuduko uhagije, intanga ntizigera ikora urugendo rwo kugera kumagi yumugore no kuyifumbira.Hamwe nibimenyetso bifatika, byerekana neza ko kuvura urumuri biteza imbere umuvuduko, ukoresheje igikoresho gikwiye cyo kuvura urumuri bisa nkibyingenzi kubashakanye batabyara.Iterambere ryimikorere ituruka kumiti yoroheje irashobora no gutsinda ikibazo cyintanga nke, kubera ko intanga ngabo nkeya zizakomeza kugera kandi (imwe murimwe) ifumbire ingirangingo.

Amamiriyoni menshi y'uturemangingo
Ubuvuzi bworoheje ntabwo butezimbere gusa, ubushakashatsi butandukanye bwerekana uburyo bushobora no kunoza umubare wintanga / kwibanda, ntibitanga intanga byihuse gusa, ahubwo nibindi byinshi.

Hafi ya selile zose mumubiri wacu zifite mitochondria - intego yo kuvura urumuri rutukura - harimo na Sertoli.Izi nintanga zitanga ingirabuzimafatizo - ahantu hakorerwa intanga.Imikorere myiza yiyi selile ningirakamaro mubice byose byuburumbuke bwumugabo, harimo kubara intanga.

Ubushakashatsi bwerekana ubuvuzi bworoheje butezimbere ubwinshi bwingirabuzimafatizo za Sertoli mumyanya ndangagitsina yumugabo, imikorere yazo (hamwe nubunini bwintanga ngabo / kubara zitanga), kandi bikagabanya umusaruro wintangangabo zidasanzwe.Muri rusange kubara intanga byagaragaye ko byateye imbere inshuro 2-5 kubagabo bafite umubare muto.Mu bushakashatsi bumwe bwakorewe muri Danimarike, umubare w’intanga wiyongereye uva kuri miliyoni 2 kuri ml ugera kuri miliyoni zirenga 40 kuri ml hamwe n’ubuvuzi bumwe gusa.

Intanga nyinshi zibara, umuvuduko wintanga wihuta, nintanga zidasanzwe ni zimwe mumpamvu zingenzi zituma kuvura urumuri ari igice cyingenzi mugutezimbere ikibazo cyuburumbuke bwumugabo.

Irinde ubushyuhe uko byagenda kose
Icyitonderwa cyingenzi kubijyanye no kuvura urumuri kubizamini:

Ibizamini byabantu bimanuka mumubiri muri scrotum kubwimpamvu ikomeye - bisaba ubushyuhe buke kugirango bikore.Ku bushyuhe busanzwe bwumubiri wa 37 ° C (98,6 ° F) ntibishobora kubyara intanga.Inzira ya spermatogenezi isaba kugabanuka k'ubushyuhe buri hagati ya dogere 2 na 5 uhereye kubushyuhe bw'umubiri.Ni ngombwa gusuzuma ubu bushyuhe busabwa mugihe uhitamo igikoresho cyo kuvura urumuri kuburumbuke bwumugabo - ubwoko bwamashanyarazi bukoreshwa cyane bugomba gukoreshwa - LED.Ndetse hamwe na LED, hari ingaruka zoroheje zo kwiyumvamo nyuma yamasomo maremare.Gukoresha igipimo gikwiye hamwe nuburebure bukwiye bwingufu zitukura urumuri rutukura nurufunguzo rwo kuzamura uburumbuke bwumugabo.Andi makuru hepfo.

Uburyo - icyo urumuri rutukura / infragre ikora
Kugirango twumve neza impamvu itara / IR rifasha muburumbuke bwumugabo nigitsina gore, dukeneye kumenya uko rikora kurwego rwa selile.

Urwego
Ingaruka zaumutuku kandi hafi yubuvuzi bwumucyobatekereza ko biva mubikorwa na mitochondria ya selile.Iyi 'Photobiomodulation'bibaho mugihe uburebure bukwiranye bwurumuri, hagati ya 600nm na 850nm, byinjijwe na mitochondrion, kandi amaherezo biganisha ku gutanga ingufu nziza no gutwika gake muri selile.
Imwe muntego nyamukuru yo kuvura urumuri ni enzyme yitwa Cytochrome C Oxidase - igice cyurwego rwo gutwara ibintu bya elegitoronike yingufu za metabolism.Byumvikane ko hari ibindi bice byinshi bya mitochondriya nabyo bigira ingaruka.Iyi mitochondriya yiganje cyane mu magi no mu ntanga ngabo.

Nyuma yigihe gito cyo kuvura byoroheje, birashoboka kubona irekurwa rya molekile yitwa Nitric Oxide iva muri selile.Iyi NTA molekile ibuza cyane guhumeka, ikabuza kubyara ingufu no gukoresha ogisijeni.Rero, kuyikura muri selile bigarura imikorere isanzwe yubuzima.Itara ritukura kandi hafi ya infragreire batekereza gutandukanya iyi molekile ihangayikishije na enzyme ya Cytochrome C Oxidase, igarura urwego rwiza rwo gukoresha ogisijeni no gutanga ingufu.

Ubuvuzi bworoheje kandi bugira ingaruka kumazi ari imbere muri selile zacu, akayubaka hamwe n'umwanya munini hagati ya buri molekile.Ibi bihindura imiterere yumubiri nu mubiri bya selile, bivuze ko intungamubiri numutungo bishobora kwinjira byoroshye, uburozi bushobora kwirukanwa hamwe no kutarwanya, enzymes na proteyine bikora neza.Izi ngaruka kumazi ya selile ntizikoreshwa gusa muri selile, ahubwo no hanze yacyo, mumwanya udasanzwe hamwe ninyama nkamaraso.

Ubu ni incamake yihuse yuburyo 2 bwibikorwa.Hano haribindi byinshi, bidasobanutse neza, ingaruka zingirakamaro zibaho kurwego rwa selire kugirango dusobanure ibisubizo bivuye kumiti yoroheje.
Ubuzima bwose bukorana numucyo - ibimera bikenera urumuri kubiryo, abantu bakeneye urumuri ultraviolet kuri vitamine D, kandi nkuko ubushakashatsi bwose bubigaragaza, urumuri rutukura kandi hafi ya infragre ni ingenzi kubantu ninyamaswa zitandukanye kugirango metabolism ibe myiza ndetse no kubyara.

Ingaruka zo kuvura urumuri ntizigaragara gusa mugice cyagenewe isomo, ariko kandi muburyo bwa gahunda.Kurugero isomo ryo kuvura urumuri kubiganza byawe birashobora gutanga inyungu kumutima.Isomo ryo kuvura urumuri ku ijosi rirashobora gutanga ubwonko ubwonko, bushobora no kuzamura imisemburo / imiterere kandi biganisha ku buzima bwiza bwumubiri.Ubuvuzi bworoheje ningirakamaro mugukuraho imihangayiko ya selile no gutuma selile zawe zikora mubisanzwe kandi selile ya sisitemu yimyororokere ntaho itandukaniye.

Incamake
Ubuvuzi bworoheje bwakozweho ubushakashatsi ku burumbuke bwabantu / inyamaswa
Hafi yumucyo Infrared yize kugirango atezimbere uburumbuke kubagore
Itezimbere ingufu mu ngirabuzimafatizo - ingenzi mu gutwita
Red Light therapy yerekana ko izamura ingufu mu ngirabuzimafatizo za Sertoli no mu ntanga ngabo, ibyo bigatuma umubare w’intanga wiyongera
Ibice byose byororoka (umugabo nigitsina gore) bisaba imbaraga nyinshi zingirabuzimafatizo
Ubuvuzi bworoheje bufasha selile kuzuza ingufu zikenewe
LED na laseri nibikoresho byonyine byizwe neza.
Uburebure butukura buri hagati ya 620nm na 670nm nibyiza kubagabo.
Hafi yumucyo Infrared hafi ya 830nm isa nibyiza kuburumbuke bwumugore.