Ibibazo bya tiroyide biragaragara muri societe igezweho, bigira ingaruka kubitsina byose no mumyaka itandukanye.Isuzumabumenyi rishobora kubura kenshi kurenza ubundi buryo ubwo aribwo bwose bwo kuvura / kwandikirwa ibibazo bya tiroyide ni imyaka mirongo inyuma yubumenyi bwa siyansi.
Ikibazo tugiye gusubiza muriyi ngingo ni - Ubuvuzi bworoshye bushobora kugira uruhare mukurinda no kuvura ibibazo bya tiroyide / metabolism nkeya?
Urebye mubitabo bya siyansi turabibonakuvura urumuriIngaruka ku mikorere ya tiroyide yizwe inshuro nyinshi, mu bantu (urugero: Höfling DB et al., 2013), imbeba (urugero: Azevedo LH et al., 2005), inkwavu (urugero: Weber JB et al., 2014), n'abandi.Kumva impamvukuvura urumuriirashobora, cyangwa ntishobora, gushimisha aba bashakashatsi, ubanza dukeneye gusobanukirwa ibyibanze.
Intangiriro
Hypothyroidism (tiroyide nkeya, tiroyide idakora) igomba gufatwa nkibintu byose abantu bagwamo, aho kuba umukara cyangwa umweru abantu bakuze gusa barwaye.Muri rusange abantu bose muri societe igezweho bafite urugero rwiza rwa hormone ya tiroyide (Klaus Kapelari et al., 2007. Hershman JM et al., 1993. JM Corcoran et al., 1977.).Hiyongereyeho urujijo, hari impamvu zitera ibimenyetso byinshi hamwe nibindi bibazo byinshi byo guhindagurika nka diyabete, indwara z'umutima, IBS, cholesterol nyinshi, kwiheba ndetse no guta umusatsi (Betsy, 2013. Kim EY, 2015. Islam S, 2008, Dorchy H, 1985.).
Kugira 'metabolism gahoro' mubyukuri ni kimwe na hypotherroidism, niyo mpamvu ihura nibindi bibazo mumubiri.Isuzumwa gusa nka hypotherroidism ivura iyo igeze aharindimuka.
Muri make, hypotherroidism nuburyo bwo gutanga ingufu nke mumubiri wose biturutse kumikorere ya hormone nkeya ya tiroyide.Impamvu zisanzwe ziragoye, harimo indyo itandukanye nibintu byubuzima nka;guhangayika, kuragwa, gusaza, ibinure byinshi, gufata karubone nkeya, gufata karori nke, kubura ibitotsi, ubusinzi, ndetse no gukora imyitozo irenze urugero.Ibindi bintu nko kubaga tiroyide yo kubaga, gufata fluoride, kuvura kwa muganga bitandukanye, nibindi nabyo bitera hypotherroidism.
Ubuvuzi bworoheje bushobora gufasha abantu ba tiroyide?
Itara & infrared itara (600-1000nm)birashoboka ko byakoreshwa muburyo bwa metabolism mumubiri kurwego rutandukanye.
1. Ubushakashatsi bumwe bwanzuye ko gukoresha itara ritukura uko bikwiye bishobora guteza imbere imisemburo.(Höfling n'abandi., 2010,2012,2013. Azevedo LH n'abandi. .Nkuko imisemburo ya tiroyide ari ikintu cyingenzi mu kuzamura ingufu z’ingufu, urashobora kubona uburyo kubura muri selile ya gland bigabanya kongera imisemburo ya tiroyide ya tiroyide - inzitizi mbi cyane.Tiroyide nkeya -> imbaraga nke -> tiroyide nkeya -> nibindi
2. Ubuvuzi bworoshyeiyo ushyizwe muburyo bukwiye ku ijosi birashobora guhagarika iyi nzitizi mbi, mubitekerezo mugutezimbere ingufu zaho, bityo byongera imisemburo ya tiroyide ya tiroyide na glande.Hamwe na glande nziza ya tiroyide yagaruwe, habaho ingaruka nziza zo hasi, kuko umubiri wose amaherezo ubona imbaraga ukeneye (Mendis-Handagama SM, 2005. Rajender S, 2011).Imisemburo ya Steroide (testosterone, progesterone, nibindi) synthesis yongeye gufata - umwuka, libido nubuzima byiyongera, ubushyuhe bwumubiri bwiyongera kandi mubyukuri ibimenyetso byose byerekana metabolisme nkeya birahindurwa (Amy Warner et al., 2013) - ndetse no kugaragara kumubiri na gukurura igitsina byiyongera.
3. Kuruhande rwinyungu zishobora guterwa na tiroyide, gukoresha urumuri ahantu hose kumubiri birashobora no gutanga ingaruka zifatika, binyuze mumaraso (Ihsan FR, 2005. Rodrigo SM et al., 2009. Leal Junior EC et al., 2010).Nubwo selile zitukura zidafite mitochondria;platine yamaraso, selile yera nubundi bwoko bwa selile ziboneka mumaraso zirimo mitochondriya.Ibi byonyine birigwa kugirango harebwe uburyo n'impamvu bishobora kugabanya urugero rwa cortisol na cortisol - imisemburo itesha umutwe ibuza gukora T4 -> T3 (Albertini et al., 2007).
4. Niba umuntu agomba gukoresha itara ritukura ahantu runaka h'umubiri (nk'ubwonko, uruhu, ibizamini, ibikomere, nibindi), abashakashatsi bamwe bavuga ko bishobora gutanga imbaraga zikomeye zaho.Ibi bigaragazwa neza nubushakashatsi bwubuvuzi bworoheje kubibazo byuruhu, ibikomere n'indwara, aho mubushakashatsi butandukanye igihe cyo gukira gishobora kugabanuka naitara cyangwa itara(J. Ty Hopkins n'abandi., 2004. Avci n'abandi., 2013, Mao HS, 2012. Percival SL, 2015. da Silva JP, 2010. Gupta A, 2014. Güngörmüş M, 2009).Ingaruka zaho zumucyo zasa nkaho zishobora kuba zitandukanye ariko zuzuzanya nibikorwa bisanzwe bya hormone ya tiroyide.
Inzira nyamukuru kandi yemerwa muri rusange kubijyanye no kuvura urumuri bitaziguye harimo kubyara ingufu za selile.Ingaruka zivugwa ko ziterwa cyane cyane na fotodissociating nitric oxyde (OYA) iva mumisemburo ya mitochondrial (cytochrome c oxydease, nibindi).Urashobora gutekereza OYA nkumunywanyi wangiza ogisijeni, nka monoxyde de carbone.OYA ahanini ihagarika ingufu zingirabuzimafatizo muri selile, ikora ibidukikije byangiza cyane imbaraga, ibyo kumanuka bizamura cortisol / stress.Itara ritukurani theorised kugirango wirinde uburozi bwa nitric oxyde, kandi bikaviramo guhangayika, mukuyikura muri mitochondria.Muri ubu buryo, itara ritukura rishobora gutekerezwa nk '' kwirinda kwanga guhangayika ', aho guhita byongera umusaruro.Nukwemerera gusa mitochondria ya selile yawe gukora neza mukugabanya ingaruka zigabanya imihangayiko, muburyo imisemburo ya tiroyide yonyine itabikora byanze bikunze.
Mugihe rero imisemburo ya tiroyide iteza imbere mitochondriya no gukora neza, hypothesis ijyanye no kuvura urumuri ni uko ishobora kuzamura no kwemeza ingaruka za tiroyide mu guhagarika molekile mbi iterwa no guhangayika.Hashobora kubaho ubundi buryo butaziguye butuma tiroyide n'umucyo utukura bigabanya imihangayiko, ariko ntituzabijyamo hano.
Ibimenyetso byumuvuduko muke wa metabolike / hypotherroidism
Umutima muke (munsi ya 75 bpm)
Ubushyuhe buke bw'umubiri, munsi ya 98 ° F / 36.7 ° C.
Buri gihe wumve ukonje (esp. Amaboko n'ibirenge)
Uruhu rwumye ahantu hose kumubiri
Ibitekerezo byiza / uburakari
Kumva uhangayitse / guhangayika
Igicu cyubwonko, kubabara umutwe
Buhoro buhoro umusatsi / urutoki
Ibibazo byo munda (impatwe, crohns, IBS, SIBO, kubyimba, gutwika, nibindi)
Inkari kenshi
Hasi / nta libido (na / cyangwa intege nke zubaka / amavuta meza yo mu gitsina)
Umusemburo / candida byoroshye
Ukwezi kutabangikanye, kuremereye, kubabaza
Kutabyara
Kunanuka vuba / kugabanuka umusatsi.Kunogora ijisho
Gusinzira nabi
Nigute sisitemu ya tiroyide ikora?
Imisemburo ya tiroyide ikorwa bwa mbere muri glande ya tiroyide (iherereye mu ijosi) nka T4, hanyuma ikanyura mu maraso ikajya mu mwijima no mu zindi ngingo, aho ihinduka mu buryo bukora - T3.Ubu buryo bukora cyane bwa hormone ya tiroyide noneho igenda muri selile zose zumubiri, ikora imbere muri selile kugirango iteze imbere ingufu za selile.Tlande ya tiroyide -> umwijima -> selile zose.
Niki mubisanzwe bitagenda neza muriki gikorwa cyo gukora?Mu ruhererekane rw'imikorere ya hormone ya tiroyide, ingingo iyo ari yo yose irashobora gutera ikibazo:
1. Tlande ya tiroyide ubwayo ntishobora gutanga imisemburo ihagije.Ibi birashobora guterwa no kubura iyode mu ndyo, kurenza aside irike ya polyunsaturated fatty acide (PUFA) cyangwa goitrogène mu ndyo, kubagwa tiroyide yabanje, icyitwa 'autoimmune' imiterere ya Hashimoto, nibindi.
2. Umwijima ntushobora 'gukora' imisemburo (T4 -> T3), kubera kubura glucose / glycogene, kurenza cortisol, kwangiza umwijima biterwa n'umubyibuho ukabije, inzoga, ibiyobyabwenge n'indwara, kurenza urugero rwa fer, nibindi.
3. Ingirabuzimafatizo ntizishobora gukuramo imisemburo iboneka.Ingirabuzimafatizo ya hormone ikora ya tiroyide ikora mubisanzwe biterwa nimirire.Amavuta ya polyunzure aturuka ku ndyo (cyangwa amavuta yabitswe arekurwa mugihe cyo kugabanya ibiro) mubyukuri abuza imisemburo ya tiroyide kwinjira mu ngirabuzimafatizo.Glucose, cyangwa isukari muri rusange (fructose, sucrose, lactose, glycogene, nibindi), nibyingenzi mukwinjiza no gukoresha imisemburo ya tiroyide ikora na selile.
Imisemburo ya tiroyide mu ngirabuzimafatizo
Dufate ko nta mbogamizi ibaho kubyara imisemburo ya tiroyide, kandi irashobora kugera mu ngirabuzimafatizo, ikora mu buryo butaziguye kandi butaziguye inzira yo guhumeka mu ngirabuzimafatizo - biganisha kuri okiside yuzuye ya glucose (muri dioxyde de carbone).Hatariho imisemburo ihagije ya tiroyide kugirango 'idapfundura' poroteyine za mitochondial, inzira yo guhumeka ntishobora kurangira kandi mubisanzwe bivamo aside ya lactique aho kuba umusaruro wa dioxyde de carbone.
Imisemburo ya tiroyide ikora kuri mitochondria na nucleus ya selile, itera ingaruka zigihe gito nigihe kirekire zitezimbere metabolisme ya okiside.Muri nucleus, T3 yatekereje kugira ingaruka kumagambo ya genes zimwe na zimwe, biganisha kuri mitochondriogenez, bisobanura byinshi / mitochondriya.Kuri mitochondriya isanzweho, itanga imbaraga zitaziguye zo kongera imbaraga binyuze muri okiside ya cytochrome, ndetse no guhumeka neza biva mu musaruro wa ATP.
Ibi bivuze ko glucose ishobora gusunikwa munzira yubuhumekero bitabaye ngombwa ko itanga ATP.Nubwo ibi bisa nkubusa, byongera ubwinshi bwa karuboni ya dioxyde de carbone, kandi bigahagarika glucose ibikwa nka acide lactique.Ibi birashobora kugaragara cyane mubarwayi ba diyabete, bakunze kubona aside irike iganisha kuri leta yitwa acide lactique.Abantu benshi ba hypotherroid ndetse batanga aside irike ikomeye kuruhuka.Imisemburo ya tiroyide igira uruhare rutaziguye mu kugabanya iyi miterere mibi.
Imisemburo ya Thyideyide ifite ikindi gikorwa mu mubiri, ikomatanya na vitamine A na cholesterol ikora inda - ibanziriza imisemburo yose ya steroid.Ibi bivuze ko tiroyide nkeya byanze bikunze itera urugero rwa progesterone, testosterone, nibindi.Imisemburo ya Thyideyide niyo misemburo ikomeye mumubiri, bivugwa ko igenga imirimo yose yingenzi hamwe numutima mwiza.
Incamake
Imisemburo ya Thyideyide ifatwa na bamwe ko ari 'master hormone' y'umubiri kandi umusaruro ushingiye ahanini kuri glande ya tiroyide n'umwijima.
Imisemburo ikora ya tiroyide itera imbaraga za mito-iyambere, gukora mitochondriya nyinshi, na hormone steroid.
Hypothyroidism ni imbaraga zingirabuzimafatizo nkeya hamwe nibimenyetso byinshi.
Impamvu ziterwa na tiroyide nkeya ziragoye, zijyanye nimirire nubuzima.
Indyo ya karbike nkeya hamwe na PUFA nyinshi mubiryo ni amakosa akomeye, hamwe no guhangayika.
Thyroidkuvura urumuri?
Nkuko glande ya tiroyide iherereye munsi yuruhu n'ibinure byijosi, hafi ya infragre ni ubwoko bwumucyo wize cyane kuvura tiroyide.Ibi birumvikana kuko byinjira cyane kuruta umutuku ugaragara (Kolari, 1985; Kolarova n'abandi., 1999; Enwemeka, 2003, Bjordal JM n'abandi., 2003).Nyamara, umutuku nku munsi muburebure bwa 630nm wize kuri tiroyide (Morcos N et al., 2015), kuko ari glande isa naho.
Amabwiriza akurikira akunze gukurikizwa mubushakashatsi:
LED / LEDmurwego rwa 700-910nm.
100mW / cm² cyangwa ubwinshi bwimbaraga
Aya mabwiriza ashingiye ku burebure bukomeye mu bushakashatsi twavuze haruguru, kimwe n'ubushakashatsi bwinjira mu ngingo na bwo twavuze haruguru.Bimwe mubindi bintu bigira ingaruka mubucengezi harimo;guswera, imbaraga, ubukana, guhuza tissue, polarisation hamwe.Igihe cyo gusaba kirashobora kugabanuka niba ibindi bintu byanonosowe.
Mu mbaraga zikwiye, itara rya LED rishobora kugira ingaruka kuri glande yose ya tiroyide, imbere ninyuma.Uburebure butukura bwumucyo ku ijosi nabyo bizatanga inyungu, nubwo hazakenerwa igikoresho gikomeye.Ibi ni ukubera ko umutuku ugaragara utinjira cyane nkuko byavuzwe.Nkugereranije, 90w + LED itukura (620-700nm) igomba gutanga inyungu nziza.
Ubundi bwoko bwatekinoroji yo kuvura urumurinkurwego rwo hasi laseri nibyiza, niba ubishoboye.Lazeri yizwe cyane mubuvanganzo kurusha LED, icyakora urumuri rwa LED rusanzwe rufatwa nkurwego rumwe (Chaves ME et al., 2014. Kim WS, 2011. Min PK, 2013).
Gushyushya amatara, incandescents hamwe na sauna ya infragre ntabwo ari ingirakamaro mu kuzamura igipimo cya metabolike / hypotherroidism.Ibi biterwa nurumuri rugari, ubushyuhe burenze / kudakora neza hamwe nubusa.
Umurongo w'urufatiro
Itara ritukura cyangwa ritarengerwabiva kuri LED (600-950nm) yizwe kuri tiroyide.
Urwego rwa hormone ya tiroyide irarebwa kandi igapimwa muri buri bushakashatsi.
Sisitemu ya tiroyide iragoye.Indyo n'imibereho nabyo bigomba gukemurwa.
LED ivura urumuri cyangwa LLLT yizwe neza kandi irinda umutekano ntarengwa.LED (700-950nm) LED itoneshwa muriki gice, umutuku ugaragara ni mwiza.
Igihe cyo kohereza: Nzeri-26-2022